TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals.
Identifieur interne : 003480 ( Main/Exploration ); précédent : 003479; suivant : 003481TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals.
Auteurs : Minou Adib-Conquy [France] ; Daniel Scott-Algara [France] ; Jean-Marc Cavaillon [France] ; Fernando Souza-Fonseca-Guimaraes [Australie]Source :
- Immunology and cell biology [ 1440-1711 ] ; 2014.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Animaux, Bactéries (immunologie), Cellules tueuses naturelles (cytologie), Cellules tueuses naturelles (immunologie), Humains, Immunité (immunologie), Mammifères (immunologie), Mammifères (microbiologie), Mammifères (virologie), Récepteurs de type Toll (immunologie), Virus (immunologie).
- MESH :
- cytologie : Cellules tueuses naturelles.
- immunologie : Activation des lymphocytes, Bactéries, Cellules tueuses naturelles, Immunité, Mammifères, Récepteurs de type Toll, Virus.
- microbiologie : Mammifères.
- virologie : Mammifères.
- Animaux, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Toll-Like Receptors.
- cytology : Killer Cells, Natural.
- immunology : Bacteria, Immunity, Killer Cells, Natural, Lymphocyte Activation, Mammals, Viruses.
- microbiology : Mammals.
- virology : Mammals.
- Animals, Humans.
Abstract
Natural killer (NK) cells are important in innate immunity, first described as guardians for the detection and clearance of transformed or virus-infected cells. Later, this cell type was revealed to be also able to recognize and respond to bacteria-infected cells. NK cells possess receptors allowing them to sense and respond to viral and bacterial patterns, including Toll-like receptors (TLRs). Initially described in other innate immune cells, particularly monocytes/macrophages, TLRs have more recently been characterized in NK cells. Controversies remain regarding the TLR expression in NK cells and their responsiveness to agonists, specifically the requirement for the presence of accessory cells, such as dendritic cells, or of accessory cytokines (IL-2, IL-12, IL-15 and IL-18) to respond to TLR agonists. Upon TLR activation, NK cells are an important source of IFN-γ and granulocyte macrophage colony-stimulating factor, cytokines necessary to fight infection but that can also contribute to deleterious inflammation if produced in excessive amounts. Here, we review the current knowledge concerning the expression of TLRs in and on NK cells and the responsiveness to their agonists and review the literature on the role of NK cells in the sensing of bacterial or viral patterns and in combatting infection.
DOI: 10.1038/icb.2013.99
PubMed: 24366517
Affiliations:
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xml:lang="en"><term>Animals</term><term>Bacteria (immunology)</term><term>Humans</term><term>Immunity (immunology)</term><term>Killer Cells, Natural (cytology)</term><term>Killer Cells, Natural (immunology)</term><term>Lymphocyte Activation (immunology)</term><term>Mammals (immunology)</term><term>Mammals (microbiology)</term><term>Mammals (virology)</term><term>Toll-Like Receptors (immunology)</term><term>Viruses (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term><term>Animaux</term><term>Bactéries (immunologie)</term><term>Cellules tueuses naturelles (cytologie)</term><term>Cellules tueuses naturelles (immunologie)</term><term>Humains</term><term>Immunité (immunologie)</term><term>Mammifères (immunologie)</term><term>Mammifères (microbiologie)</term><term>Mammifères (virologie)</term><term>Récepteurs de type Toll (immunologie)</term><term>Virus (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Toll-Like Receptors</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules tueuses naturelles</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Bactéries</term><term>Cellules tueuses naturelles</term><term>Immunité</term><term>Mammifères</term><term>Récepteurs de type Toll</term><term>Virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bacteria</term><term>Immunity</term><term>Killer Cells, Natural</term><term>Lymphocyte Activation</term><term>Mammals</term><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Mammifères</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Mammals</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Mammifères</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Mammals</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Natural killer (NK) cells are important in innate immunity, first described as guardians for the detection and clearance of transformed or virus-infected cells. Later, this cell type was revealed to be also able to recognize and respond to bacteria-infected cells. NK cells possess receptors allowing them to sense and respond to viral and bacterial patterns, including Toll-like receptors (TLRs). Initially described in other innate immune cells, particularly monocytes/macrophages, TLRs have more recently been characterized in NK cells. Controversies remain regarding the TLR expression in NK cells and their responsiveness to agonists, specifically the requirement for the presence of accessory cells, such as dendritic cells, or of accessory cytokines (IL-2, IL-12, IL-15 and IL-18) to respond to TLR agonists. Upon TLR activation, NK cells are an important source of IFN-γ and granulocyte macrophage colony-stimulating factor, cytokines necessary to fight infection but that can also contribute to deleterious inflammation if produced in excessive amounts. Here, we review the current knowledge concerning the expression of TLRs in and on NK cells and the responsiveness to their agonists and review the literature on the role of NK cells in the sensing of bacterial or viral patterns and in combatting infection.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Adib Conquy, Minou" sort="Adib Conquy, Minou" uniqKey="Adib Conquy M" first="Minou" last="Adib-Conquy">Minou Adib-Conquy</name></region><name sortKey="Cavaillon, Jean Marc" sort="Cavaillon, Jean Marc" uniqKey="Cavaillon J" first="Jean-Marc" last="Cavaillon">Jean-Marc Cavaillon</name><name sortKey="Scott Algara, Daniel" sort="Scott Algara, Daniel" uniqKey="Scott Algara D" first="Daniel" last="Scott-Algara">Daniel Scott-Algara</name></country><country name="Australie"><noRegion><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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